| 產(chǎn)品詳情 |
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| Product Name | Cl-Amidine (hydrochloride) |
| Description | Purity ≥95%. MW: 347.24. Cl-Amidine (hydrochloride) is an irreversible pan-peptidylarginine deiminase (PAD) inhibitor. It catalyzes the post-translational modification of arginine residues on histones to form citrulline. The in vitro IC50 values are 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively. It causes apoptosis in multiple cancer cell lines such as HL60, HT29, TK6, and U2-OS cells. It improves disease phenotypes in animal models of inflammatory arthritis and inflammatory bowel disease. It reduces the development of IgG autoantibodies in a collagen-induced mouse model of inflammatory arthritis. |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | Cl-amidine (hydrochloride), N-[(1S)-1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide hydrochloride, (2S)-5-(2-chloroethanimidamido)-2-(phenylformamido)pentanamide hydrochloride, (S)-N-(1-amino-5-(2-chloroacetimidamido)-1-oxopentan-2-yl)benzamide hydrochloride, N-(1S)-1-(Aminocarbonyl)-4-(2-chloro-1-iminoethyl)aminobutyl-benzamide hydrochloride |
| Gene, Accession, CAS # | CAS: 1373232-26-8 |
| Catalog # | B2802-5 |
| Price | |
| Order / More Info | Cl-Amidine (hydrochloride) from BIOVISION, INC. |
| Product Specific References | n/a |
| 產(chǎn)品資料 |
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