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產(chǎn)品名稱

LDHB (C-terminal half) Antibody from CREATIVE DIAGNOSTICS

產(chǎn)品貨號

CABT-B1820

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

n/a

產(chǎn)品品牌

CREATIVE DIAGNOSTICS

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	LDHB (C-terminal half)
Clone	polyclonal
Host Species	Rabbit
Reactive Species	human
Isotype	n/a
Format	unconjugated
Size	n/a
Concentration	n/a
Applications	WB, IHC-P
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Rabbit Anti-Human LDHB polyclonal antibody for WB, IHC-P. L-lactate dehydrogenase B chain (EC 1.1.1.27; UniProt P07195; also known as Epididymis secretory protein Li 281, Lactate dehydrogenase H chain, LDH-B, LDH-H, LDH heart subunit, Renal carcinoma antigen NY-REN-46) is encoded by the LDHB (also known as LDHBD, TRG-5, HEL-S-281) gene (Gene ID 3945) in human. Originally described by Otto Warburg and now commonly known as the Warburg effect refers to the phenomenon that many tumor cells use aerobic glycolysis instead of mitochondrial respiration for energy production to support cell growth and proliferation. Enzymes involved in the complex network of metabolic pathways are therefore being studied as potential targets for cancer treatment. Lactate dehydrogenase (LDH) is a tetrameric enzyme composed of two different subunits, LDHA and LDHB, which can assemble into five different combinations (LDH1 is comprised of four LDHB subunits; LDH2 contains three LDHB and one LDHA subunit; LDH3 contains two LDHB and two LDHA subunits; LDH4 contains one LDHB and three LDHA subunits; LDH5 contains four LDHA subunits). LDHB is ubiquitously expressed and the predominant isoform in heart muscle, while LDHA is the predominant isoform in skeletal muscle and other highly glycolytic tissues. LDH catalyzes the reversible conversion of pyruvate into lactate. An upregulation of LDH therefore reduces the oxygen dependency and ensures an efficient anaerobic/glycolytic metabolism in tumor cells. Serum LDHB levels, for example, are reported to elevate in lung cancer patients and progressively increase with the clinical stage of non-small cell lung cancer (NSCLC).
Immunogen	KLH-conjugated linear peptide corresponding to human LDHB sequence from the C-terminal half.
Other Names	n/a
Gene, Accession #	Gene ID: 3945, UniProt: P07195
Catalog #	CABT-B1820
Price
Order / More Info	LDHB (C-terminal half) Antibody from CREATIVE DIAGNOSTICS
Product Specific References	n/a
產(chǎn)品資料

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