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產(chǎn)品名稱

Glu-α-tubulin Antibody from DIANOVA GmbH

產(chǎn)品貨號

SySy302011

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

DIANOVA GmbH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	Glu-α-tubulin
Clone	1D5
Host Species	Mouse
Reactive Species	human, rat, mouse, zebrafish; eukaryotes
Isotype	IgG1
Format	purified
Size	100 μg
Concentration	n/a
Applications	IHC, Paraffin Sections (FFPE), Frozen Sections, Western Blot
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Novel marker for prostate and breast cancer: Tubulin is involved in regulation of cytoskeletal structure relating to cell differentiation, invasion and metastasis in cancer. High expression levels of tubulin and glu-tubulin, in which the C-terminal tyrosine of a-tubulin is removed, have been described in a variety of human malignant tumors. Over-expression has been reported by immunohistochemical staining in breast cancer, prostate cancer and neuroblastomas. Glu-tubulin represents a strong selective expression for cancer cells and may be usefull to immunohistochemically identify and quantify human breast and prostate cancer. Detects also cilia of Paramecium.
Immunogen	Synthetic peptide VDSVEGEGEEEGEE (14 C-terminal aa of detyrosinated α-tubulin) coupled to BSA via glutaraldehyde.
Other Names	TAT, MEC17, C6orf134, Nbla00487, Detyrosinated α-tubulin
Gene, Accession #	ATAT1, 79969
Catalog #	SySy302011
Price
Order / More Info	Glu-α-tubulin Antibody from DIANOVA GmbH
Product Specific References	Tubulin detyrosination promotes monolayer formation and apical trafficking in epithelial cells. Zink S, Grosse L, Freikamp A, Banfer S, Muksch F & Jacob R. Journal of Cell Science Oct 24. [Epub ahead of print], 2012. / Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin. Roll-Mecak A & Vale RD. Nature 451: 363-7, 2008. / Monocilia on chicken embryonic endocardium in low shear stress areas. Van der Heiden K, Groenendijk BC, Hierck BP, Hogers B, Koerten HK, Mommaas AM, Gittenberger-de Groot AC & Poelmann RE. Developmental Dynamics. 235: 19-28, 2006. / Two catalytic domains are required for protein deacetylation. Zhang Y, Gilquin B, Khochbin S & Matthias P. Journal of Biological Chemistry 281: 2401-4, 2006. / Coordination of microtubule and microfilament dynamics by Drosophila Rho1, Spire and Cappuccino. Rosales-Nieves AE, Johndrow JE, Keller LC, Magie CR, Pinto-Santini DM, Parkhurst SM. Nature Cell Biology 8: 367-76, 2006.
產(chǎn)品資料

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