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        產品名稱 Recombinant Human BMP-13 (carrier-free) from BIOLEGEND
        產品貨號 595804
        產品價格 現(xiàn)貨詢價,電話:010-67529703
        產品規(guī)格 50 μg
        產品品牌 BIOLEGEND
        產品概述
        產品詳情
        Edit&nbsp
        Product NameRecombinant Human BMP-13 (carrier-free)
        DescriptionBone morphogenetic proteins (BMPs) belong to the transforming growth factor beta (TGF-β) superfamily. BMPs play a key role in embryonic development, especially during heart, neural, and cartilage development. Around 20 BMP family members have been identified and characterized. BMPs signal through serine/threonine kinase receptors, composed of type I and II subtypes. Four type I receptors have been identified: type IA and IB BMP receptors, type IA activin receptors, and activin receptor-like kinase I. Three type II receptors have also been recognized: type II BMP receptors and type II and IIB activin receptors. BMP-13 was initially identified as a component of bovine cartilage. De-novo implantation of BMP-13 induces neo-tendon/ligament formation in rats in connective tissue healing experiments. Mutation in the GDF6 gene, encoded by BMP-13, is associated with Klippel-Feil syndrome (KFS), characterised by congenital fusion of the cervical spine vertebrae, and caused defects in joint, ligament, and cartilage formation in a transgenic mouse model. Bone marrow multipotent mesenchymal stromal cells (BM MSCs) are capable of differentiating into multiple cell types including osteoblasts and chondrocytes. Using BM MSCs it was identified that BMP-13 inhibits osteogenic differentiation, and therefore deceleration of calcium mineralization and reduction in alkaline phosphatase induction.
        Size50 μg
        Concentrationn/a
        ApplicationsBA
        Other NamesBone morphogenetic protein 13 (BMP-13), Growth differentiation factor 6 (GDF6), Cartilage-derived morphogenetic protein-2 (CDMP-2), BMP13, CDMP2
        Gene, Accession, CAS #Gene ID: 392255
        Catalog #595804
        Price
        Order / More InfoRecombinant Human BMP-13 (carrier-free) from BIOLEGEND
        Product Specific Referencesn/a
        產品資料
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