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產(chǎn)品名稱

Recombinant Human BMP-7 (carrier-free) from BIOLEGEND

產(chǎn)品貨號

595602

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

10 μg

產(chǎn)品品牌

BIOLEGEND

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Recombinant Human BMP-7 (carrier-free)
Description	Bone morphogenetic proteins (BMPs) belong to the transforming growth factor beta (TGF-β) superfamily. BMPs play a key role in embryonic development, especially during heart, neural and cartilage development. Around 20 BMP family members have been identified and characterized. BMPs signal through serine/threonine kinase receptors, and are composed of type I and II subtypes. Four type I receptors have been identified: type IA and IB BMP receptors, type IA activin receptor, and activin receptor-like kinase I. Three type II receptors have also been recognized: type II BMP receptor and type II and IIB activin receptors. BMP-7, originally identified by its properties to induce bone formation, has been identified as an anti-fibrotic molecule, antagonizing TGF-β1. Fibrosis is associated with the emergence of fibroblasts derived from endothelial cells, suggesting an endothelial-mesenchymal transition (EndMT). TGF-β1 induces endothelial cells to undergo EndMT, whereas bone BMP-7 preserved the endothelial phenotype. BMP-7 inhibits fibrosis in the kidney, lung, liver, heart, peritonium, oral submucosa tissue, and colonic wall.
Size	10 μg
Concentration	n/a
Applications	BA
Other Names	Bone morphogenetic protein 7 (BMP7), Osteogenic protein 1 (OP-1), Eptotermin alpha
Gene, Accession, CAS #	Gene ID: 655
Catalog #	595602
Price
Order / More Info	Recombinant Human BMP-7 (carrier-free) from BIOLEGEND
Product Specific References	n/a
產(chǎn)品資料

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