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產(chǎn)品名稱(chēng)

Recombinant Human CEACAM-8/CD66b (carrier-free) from BIOLEGEND

產(chǎn)品貨號(hào)

778108

產(chǎn)品價(jià)格

現(xiàn)貨詢(xún)價(jià)，電話(huà)：010-67529703

產(chǎn)品規(guī)格

500 μg

產(chǎn)品品牌

BIOLEGEND

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Recombinant Human CEACAM-8/CD66b (carrier-free)
Description	CEACAM-8, also known as CD66b and CD67, is a GPI-linked protein belonging to the immunoglobulin superfamily, carcinoembryonic antigen (CEA)-like subfamily. A homolog of CEACAM-8 has not been identified in rodents. CEACAM-8 is exclusively expressed on human granulocytes, including neutrophils and eosinophils, and is characterized as a granulocyte activation marker. CEACAM-8 is mainly found in secondary granules with low amounts on cell the surface. Upon activation of granulocytes with various stimuli, CEACAM-8 is rapidly upregulated and released from intracellular granules, leading to a high level of expression on the plasma membrane. CEACAM-8 has been reported to be involved in immune response, leukocyte migration, cell adhesion and degranulation. Engagement of CEACAM-8 with Galectin-3 activates a Src kinase, Hck, inducing cell adhesion and degranulation. In addition, CEACAM-8 constitutively associates integrin β2 and CD11b in lipid rafts, regulating cell adhesion and activation of eosinophils. CEACAM-8 can specifically bind CEACAM-6 (CD66c) through their Ig-like V-type domain in calcium-independent manner. The interaction of CEACAM-8 and CEACAM-6 mediates heterophilic cell adhesion.
Size	500 μg
Concentration	n/a
Applications	BA
Other Names	Carcinoembryonic antigen-related cell adhesion molecule 8, CEACAM-8, CEACAM8, CD67 antigen, CD66b, Carcinoembryonic antigen CGM6, Nonspecific cross-reacting antigen NCA-95
Gene, Accession, CAS #	Gene ID: 1088
Catalog #	778108
Price
Order / More Info	Recombinant Human CEACAM-8/CD66b (carrier-free) from BIOLEGEND
Product Specific References	n/a
產(chǎn)品資料

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