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產(chǎn)品名稱

MRP4/ABCC4 Antibody from BOSTER BIO

產(chǎn)品貨號

PB9144

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

100ug (sample available)

產(chǎn)品品牌

BOSTER BIO

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	MRP4/ABCC4
Clone	polyclonal
Host Species	Rabbit
Reactive Species	human, mouse, rat
Isotype	n/a
Format	immunogen affinity purified
Size	100ug (sample available)
Concentration	500ug/ml.
Applications	IHC, WB
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Rabbit IgG polyclonal Picoband? antibody for Multidrug resistance-associated protein 4(ABCC4) detection. Tested with WB, IHC-P in Human;Mouse;Rat. No cross reactivity with other proteins. ABCC4(Atp-binding cassette, subfamily c, member 4) also known as MRP4 or MOATB, is a protein that in humans is encoded by the ABCC4 gene. It belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. This gene is mapped to chromosome 13q32. ABCC4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. The antiproliferative effect of ABCC4 inhibition was related to cAMP-dependent PKA activation and CREB phosphorylation. Pharmacologic inhibition of ABCC4 activity or knockdown of ABCC4 via RNA interference resulted in reduced migration of DCs from human skin explants and of in vitro-generated Langerhans cells. It has been found that ABCC4 contributes to migration of DCs toward draining lymph nodes and therefore has a role in the initiation of an immune response.
Immunogen	E.coli-derived human MRP4 recombinant protein (Position: M1-P370).
Other Names	Multidrug resistance-associated protein 4;ATP-binding cassette sub-family C member 4;MRP/cMOAT-related ABC transporter;Multi-specific organic anion transporter B;MOAT-B;ABCC4;MRP4;
Gene, Accession #	ABCC4, UniProt: O15439
Catalog #	PB9144
Price
Order / More Info	MRP4/ABCC4 Antibody from BOSTER BIO
Product Specific References	n/a
產(chǎn)品資料

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