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產(chǎn)品名稱

Apoptotic Neutrophils, Human Antibody from HYCULT BIOTECH

產(chǎn)品貨號(hào)

HM2154F

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	Apoptotic Neutrophils, Human
Clone	BOB93
Host Species	Mouse
Reactive Species	human
Isotype	IgG1
Format	fluorescein (FITC) conjugate
Size	100 μg
Concentration	100 μg/ml
Applications	FC, WB
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	The monoclonal antibody BOB93 binds to the surface of apoptotic neutrophils. Neutrophils have been implicated in the pathogenenesis of a variety of inflammatory diseases including the adult respiratory distress syndrome, idiopathic pulmonary fibrosis, ulcerative colitis and rheumatoid arthritis. Although the neutrophil is a vital component of the body's defense against infectious agents, uncontrolled release of its toxic substances may inflict ``friendly fire'' damage on surrounding tissue and propagate the inflammatory response, leading to scarring and tissue destruction. Apoptosis leads to recognition and safe disposal of dying cells by phagocytosis. Binding of the monoclonal antibody BOB93 to apoptotic neutrophils is dependent on the presence of sialoglycoprotein fetuin, a constituent of bovine serum. Fetuin is the antigen for BOB93, and BOB93 and fetuin form a complex in solution that is necessary and sufficient for binding to apoptotic neutrophils. The antigen recognised by BOB93 may act as a ``molecular bridge'' between the surface of the apoptotic neutrophil and the phagocyte to modulate apoptotic neutrophil clearance at inflammatory sites. Human macrophage phagocytosis of apoptotic neutrophils was augmented in vitro by addition of the antigen recognised by BOB93, which does not bind to other apoptotic leukocytes.
Immunogen	n/a
Other Names	n/a
Gene, Accession #	n/a
Catalog #	HM2154F
Price
Order / More Info	Apoptotic Neutrophils, Human Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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