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產(chǎn)品名稱

Recombinant Mouse Clusterin (carrier-free) from BIOLEGEND

產(chǎn)品貨號

781004

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

25 μg

產(chǎn)品品牌

BIOLEGEND

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Recombinant Mouse Clusterin (carrier-free)
Description	Clusterin, also known as Apolipoprotein J, is a heterodimeric glycoprotein that exhibits a wide array of biological functions including lipid transportation, cell death, cell clustering, complement inhibition, tissue remodeling, reproduction, and cancer progression. Structurally, the alpha (Ser227-Glu448) and beta chains (Glu22-Arg226) of mature clusterin are assembled in an anti-parallel fashion, in which the cysteine-rich centers are linked by five disulfide bridges and are flanked by two coiled-coil alpha-helices and three amphipathic alpha-helices. The two chains are coded in a single open reading frame. In blood, circulating clusterin is predominantly associated with HDL. Approximately 22% of clusterin is present in HDL, while only about 9% is present in LDL/VLDL. Insulin resistance, obesity, and dyslipidemia are characteristics of the metabolic syndrome and type 2 diabetes. It has been shown that there is a strong negative correlation between the concentration of clusterin in HDL and both insulin sensitivity and body mass index. Thus, clusterin depletion may contribute to the loss of HDL's cardioprotective properties. In fact, clusterin levels in HDL3 increase when patients with cardiovascular diseases are treated with statin and niacin therapy. Importantly, it was shown that people who already have Alzheimer's disease have more clusterin in their blood, and that their clusterin levels correlate with faster cognitive decline in patients sufferring from Alzheimer's disease. These clinical findings suggest that clusterin may play a role in protein folding. Mature human clusterin shares a 77% amino acid sequence homology with its mouse counterpart.
Size	25 μg
Concentration	n/a
Applications	BA
Other Names	Apolipoprotein J (APOJ), Testosterone-Repressed Prostate Message 2 (TRPM-2), Ku70-Binding Protein 1 (KUB1) Complement-Associated Protein SP-40,40, Complement Cytolysis Inhibitor, Sulfated Glycoprotein 2 (SGP-2)
Gene, Accession, CAS #	Gene ID: 12759
Catalog #	781004
Price
Order / More Info	Recombinant Mouse Clusterin (carrier-free) from BIOLEGEND
Product Specific References	n/a
產(chǎn)品資料

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