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產(chǎn)品名稱

Recombinant Human NOGGIN Protein from BOSTER BIO

產(chǎn)品貨號(hào)

PROTQ13253-3

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

Various Sizes

產(chǎn)品品牌

BOSTER BIO

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Recombinant Human NOGGIN Protein
Description	Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant human Noggin is a 46 kDa disulfide-linked homodimer (120-10C) consisting of two 206 amino acid polypeptide chains. Monomeric glycosylated Noggin migrates at an apparent molecular weight of approximately 28.0-33.0 kDa by SDS PAGE analysis under reducing conditions.
Size	Various Sizes
Concentration	n/a
Applications	Cell Culture
Other Names	Noggin;NOG;
Gene, Accession, CAS #	NOG, UniProt: Q13253
Catalog #	PROTQ13253-3
Price
Order / More Info	Recombinant Human NOGGIN Protein from BOSTER BIO
Product Specific References	n/a
產(chǎn)品資料

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