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| ?NSC 45913 | ?Axon 1332
CAS [130838-36-7]
MF C4H4Cl2N4MW 179.01
Purity:
95%
Not tested
Description
References
Certificates
Categories
Extra info
Certificate of Analysis
Material Safety Data Sheet
Non Selective
Building Block; unknown pharmacology
Chemical name
2,6-Dichloro-pyrimidine-4,5-diamine
Parent CAS No.
[130838-36-7]
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| ?4μ8C | ?Axon 1902
CAS [14003-96-4]
MF C11H8O4MW 204.18
Purity:
99%
Soluble in DMSO
Description
Potent and selective IRE1 α inhibitor (IC50: 60 nM). 4μ8C blocks substrate access to the active site of IRE1 and selectively inactivates both Xbp1 splicing and IRE1-mediated mRNA degradation.
KEYWORDS: 4μ8C | Supplier | 14003-96-4 | Axon 1902 | 4mu8C | 4u8C | IRE1 inhibitor | Axon Medchem | Axon1902 | IRE1α | splicing | RNA degradation | | ?axonmedchem |
| ?Axon Ligands? Cell signaling and Oncology compound library | ?Axon 5051
CAS [N.A.]
MF #N/AMW #N/A
Purity:
98%
10 mM in DMSO
Description
Axon Ligands? Cell signaling and Oncology compound library. A unique collection of >800 compounds for cell signaling and oncology research in 96-well microtitter plate (each sample pre-dissolved in DMSO, 250 μL, 10 mM). Our continiously expanding list of compounds for cell signaling and oncology research can be found online. They are among most featured and high-profile compounds for cell signaling and oncology research.
Cherry-picking! | | ?axonmedchem |
| ?CCT 007093 | ?Axon 1821
CAS [176957-55-4]
MF C15H12OS2MW 272.39
Purity:
99%
Moderately soluble in DMSO
Description
An effective PPM1D inhibitor that selectively reduces viability of human tumour cell lines; apoptosis inducer
References
Certificates
Categories
Extra info
S Rayter et al. A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D Oncogene. 2008, 27(8), 1036-1044.?
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J P?rssinen et al. PPM1D silencing by RNA interference inhibits proliferation and induces apoptosis in breast cancer cell lines with wild-type p53. Cancer Gene Ther. 2008, 182(1), 33-39.?
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DSP Tan et al. PPM1D Is a Potential Therapeutic Target in Ovarian Clear Cell Carcinomas. Clin. Cancer Res. 2009, 15, 2269.?
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JA Bauer et al. RNA interference (RNAi) screening approach identifies agents that enhance paclitaxel activity in breast cancer cells. Breast Cancer Res. 2010, 12(3), R41.?
Certificate of Analysis
Material Safety Data Sheet
Apoptosis
Cell Signaling & Oncology
PPM1D
MAPK
EC 3.1.3.16
Protein phosphatase 1D (PPM1D) inhibitor
Chemical name
(2E,5E)-2,5-bis(thiophen-2-ylmethylene)cyclopentanone
Parent CAS No.
[176957-55-4]
Order
Size
Unit Price
Stock
10 mg
€95.00
In Stock | | ?axonmedchem |